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Thursday, March 29, 2007

Molecular Mechanisms of Apoptosis

Apoptosis is HY for the USMLE Step 1. Here is my attempt to illustrate the molecular basis of apoptosis summarized from Robins.


Anonymous said...

I really like this one since I am studying for the path shelf escpecially since you put the genes which I usually overlook when studying. I sometimes forget that apoptosis is not just "programmed cell death" but can be lymphocyte mediated. My question though is doesn't a lymphocytic response constitute inflammation and as such come under necrosis. But again maybe it depends on the inciting event and that lymphocytes can be in inflammatory as well as apoptotic reactions.

Mike said...

Apoptosis can be lymphocyte mediated such as in hepatitis when CD8+ T cells but NOT the hepatitis virus are responsible for causing hepatocytes to die(a classic pathology question). They do this via the lymphocyte mediated pathway involving the FAS-FASligand pathway as I drew out on the left side of that diagram. These hepatocytes can then be seen as council-men bodies under the light microscope. There is no inflammation though since this is not an inflammatory process.