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Thursday, March 29, 2007

Epstein Barr Virus

  • Attaches and activates B-lymphocytes CD21 (CR2) receptor
    • These activated B cells promotes T cell proliferation
    • The effected B-lymphocytes are NOT what are detected by the monospot test.
  • Atypical lymphocytes (“Downy Cells”)
    • Detected by the monospot test
      • AKA (heterophile antibody test)
    • Are CD8+ T lymphocytes
  • Associated with:
    • Heterophile positive infectious mononucleolus
    • Burkitt's Lymphoma
    • Nasopharyngeal Carcinoma
  • Structure
    • a "HAPPy" double-stranded linear DNA virus (see First Aid virus section)

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